Dilantin Sodium-Surfactant Interaction
نویسنده
چکیده
The mutual interaction between 5, 5-diphenyl hydantoin sodium salt (C15H11N2NaO2) also known as dilantin sodium (DS) and surfactants like sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB) has been studied by measuring the variation of their aggregation properties in pressence of each other. Critical micelle concentration (CMC) of DS determined by spectrophotometric and conductivity methods in found to be 0.15 mM and this value is seen to decrease significantly in presence of SDS and CTAB. The aggregation of SDS and CTAB are also highly catalysed in presence of DS. A threefold decrease in the CMC of SDS and CTAB have been observed on varying the concentration of DS in its premicellar region. Effect of temperature on micellization of SDS and CTAB have been studied at 30o, 40o and 50o C with and without DS. Physicochemical parameters has been calculated utilizing biphasic model.
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Dissolution behaviour of both 5, 5-diphenyl hydantoin sodium commonly known as dilantin sodium (DS) and its corresponding marketed capsule dilantin have been studied in aqueous as well as micellar media. Percentage dissolution of both DS and its marketed capsule are found to be low as expected in aqueous medium due to its very low solubility in water. However, their dissolution tendency is foun...
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